Another hallmark contributor to the field of xenobiotic metabolism was bernard b brodie who served as chief of the laboratory of clinical pharmacology at the us national institutes of health from 1950 to 1970 and headed a prolific group that made many substantive contributions to the study of p450 biochemistry. Xenobiotic metabolism disposition and regulation by receptors from biochemical phenomenon to predictors of major toxicities curtis j omiecinski department of veterinary and biomedical sciences center for molecular toxicology and carcinogenesis penn state university university park pennsylvania 16802 . In the present study we used a high throughput quantitative real time reverse transcription polymerase chain reaction strategy to characterize the expression profiles of 380 genes encoding proteins involved in the metabolism and disposition of xenobiotics in 10 commonly used lung cell lines a549 h292 h358 h460 h727 calu 1 16hbe 1 haeo . Xenobiotic metabolism and disposition in lung cells models 1965 contributed new reagents or analytic tools lafitte mensier jaillard kunz schughart la doetsch j mueller klieser w and groebe k 2000 proliferative activity gosset and shirali
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