Somatostatin analogue therapy is an effective and safe treatment for most growth hormone and thyrothropin secreting pituitary adenomas the potential therapeutic consequences of the presence of somatostatin receptors on clinically nonfunctioning pituitary tumours are still uncertain. Work is also in progress on applying somatostatin analogs labeled with appropriate radionuclides such as 111 indium 123 iodine 188 rhenium or 90 yttrium in cancer therapy radiolabeled somatostatin analogs could allow treatment of somatostatin receptor positive tumors by delivering a radioactive isotope to the cancer cell. Studies on such tumors in cell culture further indicated internalization of 111 in into tumor cells which is a prerequisite for a radiobiological effect from short range auger and conversion electrons attempts to systemic radionuclide therapy via somatostatin receptors in patients with neuroendocrine tumors have been initiated. Lutetium lu 177 dotatate somatostatin analogs may diminish the therapeutic effect of lutetium lu 177 dotatate specifically the therapeutic effect of lutetium lu 177 dotatate may be diminished if the timing of somatostatin analog administration is not carried out as recommended
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