Selexipag a novel oral prostacyclin receptor agonist has been shown to improve hemodynamics in a phase ii clinical trial and reduce clinical worsening in a large phase iii clinical trial involving patients with pulmonary arterial hypertension. Prostacyclin drug information from drugscom includes prostacyclin side effects interactions and indications in a randomized controlled clinical trial called the first study an increased risk of death in patients treated with epoprostenol prompted early termination of the trial 05. Several analogs of prostacyclin have been produced that have a longer half life and greater stability resulting in more favorable pharmacokinetics and bioavailability allowing administration by subcutaneous and oral routes or by inhalation prostacyclin analogs in clinical use in the united states include epoprostenol iloprost and treprostinil. Aerosolized prostacyclin on the other hand can result in a selective pulmonary vasodilatation without affecting the systemic blood pressure as shown in preliminary studies case reports no large trials exist for this type of use of the drug so far
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