Substituted heterocyclic thiourea compounds as a new class of anti allergic agents inhibiting ige fcri receptor mediated mast cell leukotriene release. A study of the structures and reactions of some methyl substituted unsaturated c 18 ester intermediates in the synthesis of a racemic mixture of 10 methyloctadecanoic acid leukotriene synthesis a new class of biologically active compounds including srs a pp 1 60 raven press new york. Compounds are now available that block the biosynthesis of the leukotrienes through specific inhibition of 5 lipoxygenase eg zileuton approved for asthma treatment in the usa experimental drugs are also available that inhibit leukotriene synthesis by inhibition of flap. 3 lta4 is a branch point in leukotriene synthesis and can be further metabolized to ltb4 a dihydroxy acid or ltc4 a peptidolipid as shown in figure 4 the conversion of lta4 to the final biologically active product is probably rate limiting for this pathway a ltb4 is generated by the action of lta4 hydrolase
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