Glucuronidation of drugs and other compounds g f dutton home worldcat home about worldcat help search search for library items search for lists search for contacts search for a library create lists bibliographies and reviews or search worldcat find items in libraries near you . Introduction uridine 5 diphosphate udp glucuronosyltransferases ugts are phase ii drug metabolizing enzymes that catalyze glucuronidation of compounds by transferring glucuronic acid from a co substrate udp glucuronic acid to substrates dutton 1980the family of ugts has been classified into two subfamilies ugt1 and ugt2 on the basis of evolutionary divergence mackenzie et al . In vitro in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans pitfalls and promises the rate of glucuronidation of a compound by human liver microsomes is highly dependent on incubation conditions the reaction phenotyping of drugs and other chemicals metabolised by glucuronidation is currently . Glucuronides of drugs are considered to be generally inactive and rapidly eliminated therefore these metabolites are often not taken into account in evaluating drug effects glucuronidation of drugs dutton gj glucuronidation of drugs and other compounds crc press boca raton florida 1980 google scholar
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