When evaluating a published report of a potential drug drug interaction it is important to consider the variables that are likely to affect the magnitude of the interaction perhaps most fundamental to understand is the dosing regimen used in the study or case report the dosing regimen of the . Enzymes responsible for a drugs metabolism a list of probe substrates inhibitors and inducers for in vitro evaluation can be found at the fdas web site on drug development and drug interactions osignificant contribution enzyme is responsible for 25 of the drugs elimination vitro phenotyping human pk. Why is it important to assess drug drug interactions what happens when drugs interact when we take medications we expect them to work in a predictable way if drugs are interacting there are a . The research sought to evaluate seven drug information resources specifically designed for analyzing drug interactions for scope completeness and ease of use and determine the consistency of content among the seven resources a cross sectional study was conducted where 100 drug drug and drug . In order to do so we cleaned our knowledge database according to the clinical significance of drug drug interactions new drug interactions taxonomy was created in four levels based on clinical
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