The protein binding of two basic drugs alprenolol and imipramine and the acidic drug naproxen was determined in plasma obtained from 23 healthy subjects a 2jold variation was found between individuals in the free fraction of the two bases while the range was even greater with naproxen pharmacology therapeutics part c clinical . Clinical pharmacology therapeutics explore this journal plasma protein binding of diphenylhydantoin in man interaction with other drugs and the effect of temperature and plasma dilution authors m lunde per knut the department of pharmacology division of clinical pharmacology and neurology at karolinska hospital karolinska . Drug protein binding clinical pharmacology and therapeutics series fundacion dr antonio esteve on amazoncom free shipping on qualifying offers. Full text full text is available as a scanned copy of the original print version get a printable copy pdf file of the complete article 695k or click on a page image below to browse page by page links to pubmed are also available for selected references. Multiple choice questions concerning phase i and phase ii drug metabolism factors affecting bioavailability volumes of distribution and drug half life pharmacology practice questions on drug metabolism pharmacokinetics and drug protein binding
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