For the development of a 2 compartment pharmacokinetic model richer data are more convenient in contrast to the currently used scarce real life outpatient data for the development and validation of this population pharmacokinetic model observational data sets retrieved from standard care settings were used. Introduction to pharmacokinetics and pharmacodynamics pharmacokinetics is currently defined as the study of the time course of drug absorption distribution metabo lism and excretion clinical pharmacokinetics is the application of pharmacokinetic principles to the safe and effective therapeutic management of drugs in an individual patient. Pharmacokinetic interpretation of data gathered during therapeutic drug monitoring dvorchik bh vesell es we review some pharmacokinetic principles that can facilitate interpretation of data obtained during therapeutic drug monitoring the one and two compartment models volume of drug distribution drug clearance organ clearance . Guidance for industry for therapeutic drug monitoring knowledge of the relationship among concentration response the traditional method of pharmacokinetic data analysis uses a two stage
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