Drug metabolism from molecules to man by benford dj jw bridges and gg gibson eds london taylor francis 1987 hard bound first edition illustrated with numerous tables and diagrams 786pp includes index very good in laminated boards 145 kilograms unpacked extra shipping charges may apply all books in stock and available for immediate shipment from winnipeg manitoba . Toxicity has been estimated to be responsible for the attrition of 1 3 of drug candidates and is a major contributor to the high cost of drug development particularly when not recognized until late in the clinical trials or post marketing the causes of drug toxicity can be organized in several . The clearance of 81 of the small molecule drugs in animals and humans were collected and used for the analysis of interspecies scaling and compared with 53 of macro molecule drugs in human clearance prediction tables 1 and and2 2. Whether or not an individuals drug metabolising capacity declines with advancing age is a vexing question there is no clear evidence that drug metabolism itself the biologically assisted chemical alteration of the administered parent molecule is less efficient in healthy old age than at younger ages whereas a decreased capacity may be associated with ill health and frailty
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