Drug interactions can also contribute to the cost of healthcare as a serious drug interaction could result in injury hospitalization or rarely death not all drug interactions are bad some medications may be better absorbed if taken with food or may have more favorable blood levels if taken with other medications that affect metabolic enzymes. Evaluating the clinical significance of drug interactions a systematic approach callahan am1 marangell lb ketter ta author information 1bipolar disorder research bronx veterans affairs medical center ny 10468 usa remembering the myriad of psychotropic drug interactions is extremely difficult. Tial and clinical significance of drug interactions with the antidepressants should therefore be considered an important skill for many prescribers and pharmacists drug interactions are broadly classified as either pharmacodynamic or pharmacokinetic pharmacody namic drug interactions often expressed as the effect a. This looseleaf but comprehensive text is likely to be useful mainly to physicians who suspect or are prospectively concerned with interactions between drugs already known to have been or about to be prescribed it will not be helpful in tracking down causes of previously unsuspected interactions . Clinically important drug drug interactions and how to manage them linda bryant mclinpharm phd tana fishman ms do frnzcgp this article is designed to be read in conjunction with the a3 table of drug interactions provided as an insert in this issue of the journal of primary health care and also available on the journal website background
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