Dose response relationships in clinical pharmacology proceedings of the esteve foundation symposium iii dose response relationships in man son vida mallorca 13 15 october 1988. In clinical pharmacology dose response curves are more likely to be evaluating responses to drugs drug dose response involves the principles of pharmacokinetics and pharmacodynamics and can be used to determine the required dose and frequency to achieve the desired response for example the desired drug effect. The importance of the dose response curve or concentration effect relation in pharmacology is perhaps most strikingly reflected in the fact that in the year in which the british pharmacological society was founded 1931 a j clark at that time professor of materia medica ie clinical pharmacology in the university of edinburgh was . Dose response data are typically graphed with the dose or dose function eg log 10 dose on the x axis and the measured effect response on the y axis because a drug effect is a function of dose and time such a graph depicts the dose response relationship independent of time. Ultimately a dose is reached beyond which no further increase in response is observed the dose response relationship can be demonstrated for interactions of chemicals with biological receptors leading to physiological responses therapeutic effects of drugs or for toxic lethal teratogenic mutagenic or carcinogenic effects of chemicals
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