Cyclosporin a recent developments in the mechanism of action and clinical application g feutren clinical research immunology sandoz ltd basle switzerland current opinion in immunology 1989 2239 245 introduction cyclosporin cs a sandimmun is now widely used as the immunosuppressant of choice for preventing graft rejection and its efficacy has also been proved in several autoimmune . Safety and efficacy of cyclosporine in the treatment of chronic dry eye clyde schultz 1 2 author des and seems to be the most widely used current therapy for des 7 21 the aim of the present manuscript is to review the safety and efficacy of cyclosporine a in the treatment of des chemistry and mechanism of action of cyclosporine. Cyclosporine is a potent immunomodulatory agent with an increasing number of clinical applications its major mode of action is inhibition of the production of cytokines involved in the regulation . Mechanism of action cyclosporine is a lipophilic cyclic peptide of 11 amino acids while tacrolimus is a macrolide antibiotic both drugs have been isolated from fungi and possess similar suppressive effects on cell mediated and humoral immune responses
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