High drug ddi value indicates better colon drug delivery absorption of drugs from the colon is monitored by colonoscopy and intubation currently gamma scintigraphy and high frequency capsules are the most preferred techniques employed to evaluate colon drug delivery systems. Colonic drug absorption and metabolism drugs and the pharmaceutical sciences peter bieck on amazoncom free shipping on qualifying offers an integrated series of chapters on the anatomical and physiological basis of drug absorption and metabolism in the colon. Anatomical and physiological basis physiological factors influencing drug absorption christine a edwards drug metabolism in the colon wall and lumen johann w faigle in vitro studies with colonic tissue cellular and subcellular preparations pierre dechelotte and michael f schwenk scintigraphic techniques in studying colonic . Criteria for selection of drug for cdds drug candidate drugs which show poor absorption from the stomach or intestine including peptide are most suitable for cddsthe drugs used in the treatment of ibd ulcerative colitis diarrhea and colon cancer are ideal candidates for local colon delivery. As cr formulations are designed to release the drug during 12 24 h it is obvious that drug absorption in colon is a prerequisite for oral cr development 3 13 despite the fact that there are various in vitro and in situ models to predict the absorption and permeability in small intestine there is less knowledge regarding the large
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