Which mechanism of action does the nurse know is true for nitroprusside it directly relaxes vascular smooth muscle allowing dilation of peripheral arteries and veins calcium channel blockers adverse effects dizziness hypotension constipation peripheral edema. By acting on vascular smooth muscle they reduce contraction of the arteries and cause an increase in arterial diameter a phenomenon called vasodilation ccbs do not work on venous smooth muscle by acting on cardiac muscles they reduce the force of contraction of the heart. Fleckenstein a specific pharmacology of calcium in myocardium cardiac pacemakers and vascular smooth muscle annu rev pharmacol toxicol 1977 17149 166 galizzi jp fosset m lazdunski m properties of receptors for the ca2 channel blocker verapamil in transverse tubule membranes of skeletal muscle. The contractile characteristics and the mechanisms that cause contraction of vascular smooth muscle vsm are very different from cardiac muscle vsm undergoes slow sustained tonic contractions whereas cardiac muscle contractions are rapid and of relatively short duration a few hundred milliseconds. Different classes of calcium channel blockers there are three chemical classes of ccbs they differ not only in their basic chemical structure but also in their relative selectivity toward cardiac versus vascular l type calcium channels the most smooth muscle selective class of ccbs are the dihydropyridines because of their high vascular
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