Dual 12 15 and 5 lipoxygenase deficiency in macrophages alters arachidonic acid metabolism and attenuates peritonitis and atherosclerosis in apoe knock out mice these mediators are predominantly formed from arachidonic acid for a review see ref 3. In vitro studies using cells from human peripheral blood and peritoneal cavity of mice was conducted adherent cells were prelabelled with 3 h arachidonic acid before exposure to live and heat killed salmonella typhi release of arachidonic acid metabolites in the culture medium was determined by liquid scintillation counting. Arachidonic acid aa is the most biologically relevant omega 6 fatty acid and in the lipid membrane of a cell serves as the fatty acid that is compared against the two fish oil fatty acids epa and dha in constituating an omega 36 ratio recent data suggests a daily intake of 50 250mg of arachidonic acid with some sources estimated levels of up to 500mg daily arachidonic acid intake . The role of arachidonic acid metabolism in the pathogenesis of atherosclerosis principal investigator lisa ang community and health care costs on society atherosclerosis commonly referred to as hardening of the arteries is an inflammatory disease and is the primary cause of heart attacks strokes lower limb loss in diabetics
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