Phytomedicine vol 2 1 pp 7 15 1995 c1995bygustavfischerverlag stuttgart jenanewyork the intestinal absorption of orally administered hydrolytic enzymes and their effects in the treatment of acute herpes zoster as compared with those of oral acyclovir therapy michael w kleine1 gerhard m stauder2 edward w beese3 1 egenhofenstr 8 82152 planegg germany. Get this from a library absorption of orally administered enzymes michael l g gardner k j steffens this book is a compilation of papers that arose from a multidisciplinary workshop held at the walter straub institute for pharmacology and toxicology in munich in september 1993 to review the current . This book is a compilation of papers that arose from a multidisciplinary workshop held at the walter straub institute for pharmacology and toxicology in munich in september 1993 to review the current state fo knowledge relating to the oral administration of enzymes especially proteases as therapeutic agents. The most desirable route of administration for therapeutic agents is oral as it avoids pain and risk of infection associated with parenteral administration and thereby increases patient compliance however most of the orally administered drugs display low systemic availability and diminished efficacy. Following absorption through the oral mucosa drugs directly enter the systemic circulation and thus initially circumvent the hepatic circulation this special feature of the buccal mucosa may be utilized clinically to assure the prompt absorption of drugs that cannot be given orally due to first pass metabolism
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