An improved understanding of cardiovascular cell cell and cell matrix interactions stem cell biology the influence of the microenvironment on cell fate and integration of regeneration with the principals of developmental biology have collectively resulted in more clinically applicable approaches. Abstract there is an urgent clinical need to develop new therapeutic approaches to treat heart failure but the biology of cardiovascular regeneration is complex. In this review we discuss computational cell based tissue and animal models that have been used in the study of cardiovascular regenerative biology or in the testing of therapeutic approaches to restore cardiac function following disease or injury. The cardiovascular biology journal club course is designed to highlight the advances in cardiovascular science and medicine that will soon form the foundation for novel diagnostic prognostic and therapeutic approaches to treating heart disease. Model systems for cardiovascular regenerative biology jessica c garbern1 christine l mummery2 and richard t lee3 1boston childrens hospital boston massachusetts 02115 2department of anatomy embryology leiden university medical center 2300 rc leiden the netherlands 3brigham and womens hospital and partners research facility cambridge massachusetts 02139
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