Evidence has accrued to suggest that calcium antagonists also may be protective against acute radiocontrast induced nephrotoxicity finally the renal hemodynamic and natriuretic effects of calcium antagonists commend their use as antihypertensive agents in the management of essential hypertension and transplant associated hypertension. Calcium antagonists do not affect the vasodilated isolated perfused kidney but they do dramatically alter the response of the kidney to vasoconstrictor agents. During the past decade attention has focused on the effects of calcium antagonists on renal function recent studies using diverse videomicroscopic techniques including the isolated perfused hydronephrotic rat kidney model which permits direct visualization of afferent and efferent arterioles have demonstrated that calcium antagonists acutely antagonize preglomerular vasoconstriction. Chapter 10 calcium antagonists and the kidney diseases desperate grown by desperate appliances are relieved or not at all w shakespeare in hamlet having outlined the essential characteristics of the calcium antagonists and
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